0030 25510 30610       dasimako@admin.duth.gr   
   DUTH-University Campus, 68100 Alexandroupolis

Features of the program

  • Combined training in classroom, laboratory and clinic throughout the program

  • Hands-on training with modern molecular, immunological and microbiological laboratory techniques for diagnosis of infectious diseases. Exposure to practical clinical laboratory issues.

  • Summer Internship in Diagnostic or Research Laboratories and Clinics to expose students to future working environment.

  • Seminars on  ‘hot’ topics on infectious diseases-International Medicine by invited experts in the field

Courses 1st Semester

Molecular and Clinical Bacteriology

ECTS 6

Coordinators
Asst. Prof. Maria Panopoulou
Asst. Prof. Ioannis Kourkoutas

Course Layout

Section I (4h)

  • Introduction to Bacteriology
  • Bacterial genetics
  • Pathophysiology of bacterial infections

Section II (4h)

  • Mycobacterium tuberculosis
  • Non-tuberculosis mycobacteria
  • Brucella spp

Section III (4h)

  • Enterobacteriaceae
  • Campylobacter spp
  • Vibrios
  • Helicobacter pylori

Section IV (4h)

  • Bacillus anthracis
  • Clostridium spp
  • Corynebacterium diptheriae
  • Spirochaetales

Section V (4h)

  • Rickettsia
  • Chlamydia
  • Human microbiome

Molecular and Clinical Virology

ECTS 6

Coordinators
Prof. Penelope Mavromara
Asst. Prof. Ioannis Karakasiliotis

Course Layout

SECTION I (2h)

  • Introduction to Virology

(General concepts on: What is a virus?/life cycle/genetics and genomics/emerging and re emerging viruses/ oncogenic viruses/ vector borne viruses)

SECTION II (4h)

Positive strand RNA viruses

  • Picornaviruses : Polio and other viruses
  • Flaviviruses: HCV and other viruses
  • Coronaviruses: SARS and other viruses
  • Hepaciviruses: HCV

SECTION III (5h)

Negative strand RNA viruses

  • Orthomyxoviruses: Influenza
  • Paramyxoviruses : Measles , Rubella
  • Filoviruses: Ebola
  • Rhabdoviruses: Rabies

SECTION IV (5h)

DNA viruses

  • Papillomaviruses
  • Polyomaviruses
  • Herpesviruses : HSV1/2, VZV, CMV, EBV, Kaposi Sarcoma
  • Poxviruses : Vaccinia
  • Adenoviruses

SECTION V (2h)

  • Retroviruses: HTVL I/II , HIV

SECTION VI (2h)

  • Hepadnaviruses: HBV

SECTION VII (2h)

  • Viral vectors in Gene Therapy

Mycology and Parasitology

ECTS 5

Coordinators
Asst. Prof. Maria Panopoulou
Assoc. Prof. Katerina Chlichlia

Course Layout

SECTION I (4h)

  • Molecular and Clinical Parasitology (Part 1)
  • Biology and life cycle of human parasites, Pathophysiology of parasitic infections, Intestinal and urogenital protozoa
  • Εntamoeba histolytica
  • Giardia lamblia, Dientamoeba fragilis, Trichomonas vaginalis
  • Balantidium coli
  • Ιsospora belli, Sarcocystis, Cryptosporidium, Cyclospora

SECTION II (2h)

  • Molecular and Clinical Parasitology (Part 2)
  • Blood and tissue parasites, Arthropods
  • Plasmodium spp, Leishmania, Τrypanosoma, Τοxoplasma, Babesia
  • Arthropoda

SECTION III (4h)

  • Molecular and Clinical Parasitology (Part 3)
  • Helminths: Nematodes,Trematodes, Cestodes
  • Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichinella spiralis
  • Schistosoma
  • Taenia, Echinicoccus

SECTION IV (4h)

  • Molecular and Clinical Mycology (Part 1)
  • Fungal classification, structure and morphology
  • pathogenicity and pathogenesis of fungal infections
  • Superficial fungal infections

SECTION V (4h)

  • Molecular and Clinical Mycology (Part 2)
  • Systemic fungal infections
  • Endemic dimorphic fungi

Immunology of Infectious Diseases and Vaccines

ECTS 5

Coordinators
Assoc. Prof. Katerina Chlichlia
Assoc. Prof. Aglaia Pappa

Course Layout

SECTION I (4h)

Introduction to Immunology

  • Innate immunity to pathogens
  • Adaptive immunity to pathogens (Humoral and Cell-mediated immune responses)

SECTION II (4h)

Immune responses to pathogenic microorganisms

  • Immune responses to intracellular and extracellular bacteria (Staphylococcus, Mycobacteria etc.)
  • Immune responses to viruses (Influenza, Polio, Measles, HIV, HSV, HPV)
  • Immune responses to parasites and fungi (Trypanosoma, Leishmania, Schistosoma, Plasmodium, Candida)

SECTION III (2h)

  • Pathogen-induced evasion of protective immune responses.

SECTION IV (2h)

  • Microbiome, microbiota and host immune system.

SECTION V (4h)

Immunization – Vaccines

  • Active Immunization, types of Vaccines, Adjuvants
  • Design of new generation vaccines

Pathogenetic mechanisms and Genetic variability

ECTS 3

Coordinators
Prof. Stavroula Veletza
Asst. Prof Giannoulis Fakis

Course Layout

SECTION I (2h)

  • Introduction to Polymorphisms in Host Genetics
  • Prognostic significance of host gene polymorphisms​

SECTION II (2h)

  • Lost genetic polymorphisms and therapy outcome
  • Host genetic polymorphisms and desease severity

​SECTION III (2h)

  • Inheritabe immunity to infectious diseases

SECTION IV (2h)

  • Impact of host genetic polymorphisms on vaccine induced antibody response
  • Genetic Polymorphisms in Host Innate Immune Sensor Genes

Pathogenetic mechanisms and metabolism

ECTS 2

Coordinators
Prof. Ioannis Tentes
Asst. Prof. Katerina Katsani

Course Layout

SECTION I (2h)

Introduction to common host metabolic processes targeted by pathogens

  • Main metabolic pathways (carbohydrate, lipid, protein) – energy metabolism
  • Control mechanisms of host metabolism (substrates, intermediates, enzymes).
  • Tissue/organ metabolic priorities and energy resources usage maintaining blood glucose homeostasis

SECTION II (2h)

How the host’s metabolic priorities are diverted as a result of pathogenic invasion

  • The paradigm of bacterial infection
  • The paradigm of Hepatitis C virus
  • The paradigm of parasitic infection.

SECTION III (2h)

Nutrition and infection.

  • Iron metabolism and infection.
  • Μalnutrition and inflammation.

SECTION IV (2h)

Oncogenic viruses and metabolism.

  • The common pathways of energy usage in viral infection and cancer.
  • Oxidative stress, apoptosis and extreme metabolic scenarios.

Good Laboratory Practice, Biosafety and Bioethics

ECTS 2

Coordinators
Asst. Prof. Maria Panopoulou

Course Layout

SECTION I (2h)

  • Good Laboratory Practice and Good Manufacture Practice – strategies in managing health and safety

SECTION II (2h)

  • Biosafety: Biologic agents – Biosafety Levels – Risk assessment

SECTION III (2h)

  • Biosafety: Safety in working with bacteria and viruses

SECTION IV (2h)

  • Biosafety: Safety in working with laboratory animals

Courses 2nd Semester

Biostatistics and Molecular Epidemiology

ECTS 5

Coordinators
Asst. Prof. Ioannis Karakasiliotis
Asst. Prof. Georgios Boulougouris

Course Layout

SECTION I (2h)

  • Global disease control
  • European and American disease control centers
  • Greek disease control center and legislation
  • World health organizations, Reference centers and Reporting

SECTION II (2h)

  • Molecular Genetics of Infectious agents
  • Informatics tools for molecular genetics
  • Phylogenetic trees
  • Molecular evolution

​SECTION III (2h)

  • ​Molecular typing of bacterial pathogens
  • Epidemiology of antibiotics resistance
  • Examples of bacterial molecular epidemiology (tuberculosis, helicobacter)
  • Evolution of virulence
  • Molecular typing of viruses
  • Virus evolution and quasispecies
  • Examples of viral molecular epidemiology (Influenza, viral hepatitis)

​SECTION IV (2h)

  • ​Biostatistics of Infectious diseases
  • ​Introductory Concepts
  • Discrete and continuous Probabilities, Characteristic Distributions
  • Statistical Inference: Analysis of variance ANOVA, Z and t tests
  • Sample size and Power
  • Survival Analysis

Molecular Diagnostics

ECTS 5

Coordinators
Asst. Prof. Alexios Galanis
Asst. Prof. Maria Panopoulou
Asst. Prof. Ioannis Karakasiliotis
Prof. Penelope Mavromara

Course Layout

SECTION I (4h)

  • ​Introduction to molecular methods
  • Current molecular technologies in infectious diseases diagnosis

SECTION II (4h)

  • ​Advanced molecular diagnostic technologies in Infectious Diseases (NGS, microarrays, proteomics…)

SECTION III (4h)

  • ​Current and future molecular diagnostics in Bacteriology
  • Troubleshooting

SECTION IV (4h)​

  • Current and future molecular diagnostics in Virology

International Medicine – Global Health

ECTS 5

Coordinators
Assoc. Prof. Konstantinos Mimidis
Asst. Prof. Vassiliki Dalla

Course Layout

SECTION I (4h)

  • International Medicine: a scientific discipline or a humanistic necessity
  • International Medicine in Greece
  • Introduction to International Medicine​

SECTION II (4h)

  • ​Global Health​

SECTION III (4h)

  • NCD-Diabetes as a global health issue
  • Infections in Diabetes Mellitus
  • Trauma from a global perspective
  • Infections related to trauma

SECTION IV (4h)

  • Integrated care for tuberculosis
  • Global HIV epidemic
  • Hepatitis A,B,C,D, E
  • Malaria

Antimicrobial Agents and Resistance

ECTS 4​

Coordinators
Asst. Prof. Periclis Panagopoulos
Asst. Prof. Maria Panopoulou
Prof. Efstratios Maltezos

Course Layout

SECTION I (3h)

  • ​Classification of antimicrobial agents
  • Mode of action of antimicrobial agents

SECTION II (5h)

  • ​Molecular mechanisms of antimicrobial resistance
  • Antimicrobial stewardship

SECTION III (1h)

  • ​Biofilms

SECTION IV (3h)

  • Control and prevention of hospital acquired infections
  • Antimicrobial drug development

Immigrant and Tropical Medicine

ECTS 3

Coordinators
Assoc. Prof. Konstantinos Mimidis
Prof. Efstratios Maltezos

Course Layout

SECTION I (4h)

  • General approach to the patient
  • Gastrointestinal Infections in Tropical Medicine
  • Respiratory Infections
  • Cardiovascular Infections

SECTION II (4h)

  • Infections in Haematology
  • Infections in Ophtalmology
  • Infections in Neurology
  • Infections in Nephrology

SECTION III (4h)

  • Doctors without boarders-experiences-challenges
  • Travel and Infections
  • Musculoskeletal Infections in Tropical Medicine

SECTION IV (4h)

  • Migration and Tropical Medicine: experiences from the field
  • Imaging in Tropical Medicine
  • Pathology in Tropical Medicine

Zoonotic Diseases – The ‘One Health’ concept

ECTS 3

Coordinators
Prof. Efstratios Maltezos
Assoc. Prof. Katerina Chlichlia

Course Layout

SECTION I (2h)

  • ​Zoonotic Diseases and “One Health” concept
  • Interplay between human health, animal health and environment
  • Most common zoonotic diseases

​​SECTION I (2h)

  • Metazoan Zoonoses
  • Trichinosis, Cysticercosis, Hydatid disease

SECTION II (3h)

  • ​Viral Zoonoses
  • Rabies, Avian Influenza, Viral hemorrahagic fevers, West-Nile fever, Hepatic E virus infections (HEV), Zika virus infections

​​​SECTION II (1h)

  • Prion diseases: spongiform encephalopathies (TSEs)

SECTION III (4h)

  • ​Bacterial Zoonoses
  • Anthrax, Brucellosis, Leptospirosis, Listeriosis, Lyme disease, Psittacosis, Q fever, Tularemia, Cat scratch disease, Plague, Rickettsial infections
  • Enteric infections: Salmonellosis, Shigellosis, Campylobacter spp, Yersina spp.

SECTION IV (4h)

  • ​Protozoan Zoonoses
  • Leishmaniasis, Cryptosporidiosis, Giardiasis, Toxoplasmosis

Clinical Laboratory Practical Training

ECTS 5

Course Layout

SECTION I (2h)

  • ​Molecular diagnostic techniques

SECTION II (2h)

  • Molecular mechanisms of resistance

SECTION III (2h)

  • ​Molecular diagnostic techniques

SECTION IV (2h)

  • ​Molecular diagnostic techniques

The total ECTS credits required to obtain the Master of Science in Infectious Diseases and International Medicine is ninety (90). Students complete 60 ECTS of coursework in semesters A and B. Attendance of lectures and laboratory sessions is mandatory. The dissertation thesis during the final semester (20 ECTS) and the seminars (10 ECTS) will provide students with the opportunity to consolidate and apply the knowledge acquired in coursework.